Septic thrombosis of the cavernous sinuses (or cavernous sinus thrombophlebitis [CST]) is a dramatic and potentially lethal illness, which is still occasionally seen by clinicians. Before the availability of antimicrobial agents, mortality from CST was near 100%, but it markedly decreased to approximately 20% to 30% during the antibiotic era , yet severe, process typically arising from infections of the paranasal sinuses (predominately ethmoid and/or sphenoid sinusitis) and less commonly, otogenic, odontogenic, and pharyngeal sources Septic cavernous sinus thrombosis: an unusual and fatal disease. Due to the high case-fatality rate and low yield rate of blood cultures, fungal CST should be suspected in an immunocompromised patient with ophthalmic complaints that progress from one eye to the other Cavernous sinus thrombosis from a septic etiology occurs due to embolization of bacteria which trigger thrombosis that becomes trapped within the cavernous sinus. The subsequent reduction in venous drainage results in facial and periorbital edema, ptosis , proptosis, chemosis, painful eye movements, papilledema , retinal venous distension and loss of vision 7
Septic thrombosis of the cavernous sinuses most commonly follows infections of the middle third of the face due to Staphylococcus aureus. Other antecedent sites of infection include paranasal (usually sphenoid) sinusitis, dental abscess and, less often, otitis media. Fever is a nearly constant finding, but headache may not be prominent Purpose: Septic cavernous sinus thrombosis (CST) is a rare complication of infections in the head and neck area. CST is notorious for its bad prognosis, with high mortality and morbidity rates described in literature
Although my study concerns itself chiefly with the aseptic types of thrombosis of the cavernous sinus, I shall be obliged to cover all the phases of this subject. ANATOMIC CONSIDERATIONS. The sinuses of the dura mater 1 are venous channels lying between the inner and the outer layer of the dura. They are rigid tubes, which always remain open. The mortality rate of septic cavernous sinus thrombosis is approximately 20-30%, even after the introduction of antibiotics. 1 The morbidity and long‐term complications necessitate prompt diagnosis and treatment. The cavernous sinus and dural sinuses are more vulnerable to septic thrombosis, because they lack valves The cavernous sinuses which are the most commonly affected sinuses in septic cerebral venous thrombosis, are paired sinuses located in the base of skull, superolateral to the sphenoid air sinuses. These are separated from sphenoid air sinuses by thin bone, or sometime only by soft tissue, if the bone is not fully formed  Septic cavernous sinus thrombosis (CST) is a rare and fatal disease. Clinical presentations in the early stage are nonspecific, and the sensitivity of cranial axial computed tomography (CT) with thick section is low. This study analyzed the clinical manifestation and neuroimaging findings in patients with septic CST in a medical center in Taiwan 1. Introduction. Septic cavernous sinus thrombosis (SCST) is a rare, yet severe, thrombophlebitic process typically arising from infections of the paranasal sinuses and, less commonly, otogenic, odontogenic, and pharyngeal sources 63.SCST can affect individuals of all ages, but most often occurs in young adults. 9 Clinical symptoms of SCST arise from obstruction of venous drainage from the.
Septic cavernous sinus thrombosis (SCST) is a rare, yet severe, process typically arising from infections of the paranasal sinuses (predominately ethmoid and/or sphenoid sinusitis) and, less commonly, otogenic, odontogenic, and pharyngeal sources Septic cavernous sinus thrombosis (CST) is a rare life-threatening condition which results mainly from sinusitis (sinogenic) and facial infections. Paediatricians must maintain a high index of suspicion for CST in cases of orbital cellulitis, especially when ocular nerve palsies are out of proportion to the degree of orbital swelling These dural layers send trabeculae that give the sinuses a reticular pattern and can thereby trap bacteria, thrombi, or emboli. Bacteria also stimulate thrombogenesis by releasing toxins or by causing tissue damage. Growth of the thrombus is thought to block antibiotic penetration in the cavernous sinuses
. The common sites of primary infection are the medial face, orbits, tonsils, soft palate, sphenoid and ethmoid sinuses With Septic Thrombosis of the Cavernous Sinuses* Abnormality Frequency, % Fever 80-100 Ptosis Proptosis Chemosis Cranial nerve palsies Lethargy 50-80 Headache Periorbital swelling Papilledema Venous engorgement Decreased visual acuity 50 Sluggish or dilated pupil Periorbital sensory loss Decreased corneal reflex Nuchal rigidity Diplopia. Introduction: Septic cavernous sinus thrombosis (CST) is a rare condition that can result in high mortality and morbidity rates if not treated immediately. CST may be aseptic or septic Septic cavernous and lateral sinus thrombosis: modern diagnostic and therapeutic principles. Tveterås K(1), Kristensen S, Dommerby H. Author information: (1)Department of Otolaryngology, St. Joseph's Hospital, Esbjerg, Denmark. The incidence of both lateral and cavernous sinus thrombophlebitis has been significantly reduced in the antibiotic era
septic cavernous sinus thrombosis. In this study, we analyzed the contrast-enhanced high-resolution CT findings in eight consecutive pa-tients with the clinical diagnosis of septic cavernous sinus thrombosis in comparison with findings in 30 healthy control subjects. The CT examinations were also assessed with respect to the presence of concom The cavernous sinuses which are the most commonly affected sinuses in septic cerebral venous thrombosis, are paired sinuses located in the base of skull, superolateral to the sphenoid air sinuses. These are separated from sphenoid air sinuses by thin bone, or sometime only by soft tissue, if the bone is not fully formed 
Septic cavernous sinus thrombosis (CST) is thrombophlebitis in the cavernous sinus. It is an unusual complication of paranasal sinusitis, otitis media and, less often, pharyngitis and dental infection, affecting the anatomic structures running in the cavernous sinus.1-3 Ophthalmoplaegia may be the presenting symptom of cavernous sinus thrombosis Septic thrombosis of the cavernous sinus is a potentially lethal illness with mortality rates reported between 20% and 30%. 1 Sinusitis, especially involving the sphenoid and ethmoid sinuses, is the most common cause of cavernous sinus thrombosis while other locoregional infections involving dental aetiology are less common. Septic thrombosis most frequently involves the cavernous sinuses (96 cases). Facial or sphenoid air sinus infection often precede cavernous-sinus disease. In addition to the classical signs of proptosis, chemosis, and oculomotor paralysis, isolated sixth-nerve palsy and hypo- or hyperesthesia of the fifth nerve may be found Cavernous sinus thrombosis is a potentially fatal scenario that should be added to the sequels of neglected halo pin site infection. • Diagnosis of septic CST requires a high degree of clinical suspicion to the cavernous sinuses as a contiguous phlebitis/ thrombophlebitis or as septic emboli that become trapped by the numerous trabeculations within the cavernous sinus.1,3Bacteria are potent stimulators of thrombosis by mechanisms that include release of coagulative substances or toxins causing tissue damage, and the thrombus itself is an excellen
Since septic cavernous sinus thrombosis (CST) is mainly a complication of facial abscesses and septic lateral sinus thrombosis (LST) is almost invariably due to chronic otitis media, both conditions are of clinical relevance to the otolaryngologist. The predominant bacterium in septic CST is Staphylococcus aureus whereas in septic LST the bacterio Septic cavernous sinus thrombosis (CST) is known as a rare, life-threatening complication of infections in the head and neck area. Although the use of antibiotics has improved the prognosis, CST is still notorious for its high mortality and morbidity rates Septic Cavernous Sinus Thrombosis Some of the infections that can cause septic cavernous sinus thrombosis include adjacent infections, like cellulitis or an abscess in the mouth or bridge of the nose, and bacterial nasal infections. Sinusitis is the most common cause. Other risks include cellulitis around the eyes, tonsillitis, pharyngitis, ear infections, and dental infections Septic thrombosis of the cavernous sinus is a potentially lethal illness with mortality rates reported between 20% and 30%. 1 Sinusitis, especially involving the sphenoid and ethmoid sinuses, is the most common cause of cavernous sinus thrombosis while other locoregional infections involving dental aetiology are less common. 2 Cavernous sinus thrombosis (CST) was initially described by Bright in 1831 as a complication of epidural and subdural infections. The dural sinuses are grouped into the sagittal, lateral (including the transverse, sigmoid, and petrosal sinuses), and cavernous sinuses
Septic cavernous sinus thrombosis (CST) is an extremely rare diagnosis that is characterized by nonspecific signs and symptoms. It is often precipitated by a recent facial or sinus infection , as the venous supply from these areas drains into the cavernous sinus. As exemplified in the case presented herein, patients with septic CST can present atypically without any known precipitating. BACKGROUND Septic cavernous sinus thrombosis (SCST) is a rare but severe disease that is associated with signiﬁcant morbidity and mortality.1 2 In most cases, SCST occurs secondary to the spread of facial and paranasal sinus or dental infections by veins or direct extension. The microbiology of SCST is well documented This article reviews the contemporary literature for septic cavernous sinus thrombosis (CST) with a focus on anticoagulation. Modern emphasis is placed on suspecting and treating this condition early, which is aided by recognizing clinical features attributable to sepsis, orbital venous congestion, and involvement of cranial nerves within each cavernous sinus Septic cavernous sinus thrombosis is a rare and potentially life-threatening complication of infections involving the paranasal sinuses or the middle one-third of the face
Septic cavernous sinus thrombosis. Most common. Lots of trabeculae to trap bacteria. Clinical manifestations Headache and cranial nerve palsies should raise your suspicion! Fever, periorbital edema. Pain is usually unilateral, retroorbital and frontal in nature with radiation to the occiput Severe infection involving complications of paranasal sinus and facial infections (e.g. manipulated midface abscesses, furuncles) Frequent extension of thrombosis to opposite sinus. Low frequency, but high rate of morbidity/mortality. Structures within the Cavernous Sinus. V1 and V2 We report a case of cavernous sinus thrombosis in a 55-year-old Chinese man who presented with headache, ophthalmoplegia and ptosis. Campylobacter rectus was eventually isolated from the blood cultures. He was treated with broad-spectrum antibiotics, anticoagulation and steroids with improvement in his condition. To our knowledge, this is the first documented case of septic cavernous sinus. The cavernous sinuses and their connections are devoid of valves, consequently bidirectional spread of infection and thrombi can occur throughout this network. Infection of the thrombus within the cavernous sinuses cannot be proven in the vast majority of antemortem cases of septic CST, but has been demonstrated in postmortem studies Cavernous sinus thrombosis is usually septic, but can also be aseptic. Septic cases can follow central facial infections, especially within the danger triangle of the face (from the corners of the mouth to the bridge of the nose). These include abscess or cellulitis, sinusitis (especially sphenoiditis and ethmoiditis), dental infections.
Septic cavernous sinus thrombosis is an uncommon clinical syndrome with a high morbidity and mortality. The commonest bacterial pathogen is Staphylococcus aureus. We describe the study of a patient with cavernous sinus thrombosis and meningitis caused by community-acquired methicillin-resistant S. aureus (CA-MRSA) infection Septic cavernous sinus thrombosis (CST) is a rare life-threatening condition which results mainly from sinusitis (sinogenic) and facial infections. Paediatricians must maintain a high index of suspi-cion for CST in cases of orbital cellulitis, especially when ocular nerve palsies are out of proportion to the degree of orbital swelling
Mackintosh HT: Septic cavernous sinus thrombosis—a case report. Aust NZ J Ophthalmol 19: 169 - 171, 1991 Mackintosh HT: Septic cavernous sinus thrombosis—a case report. Aust NZ J Ophthalmol 19: 169-171, 199 Southwick FS, Richardson EP, Swartz MN.Septic thrombosis of the dural venous sinuses.Medicine 1986;65:82±106. Levine SR, Twyman RE, Gilman S. The role of anticoagulation in cavernous sinus thrombosis.Neurology 1988;38:517±22. - Early administration of heparin may serve to prevent spread of thrombosis to the other cavernous sinus as well as.
Background. Septic cavernous sinus thrombosis (SCST) is a rare but severe disease that is associated with significant morbidity and mortality.1, 2 In most cases, SCST occurs secondary to the spread of facial and paranasal sinus or dental infections by veins or direct extension. The microbiology of SCST is well documented . Arch Neurol. 1988 May. 45(5):567-72. . Ferro JM, Canhao P, Bousser MG. Cerebral vein and dural sinus thrombosis in elderly patients. Stroke.
Cavernous sinus thrombosis is typically caused by an infection that has spread beyond the face, sinuses, or teeth. Less commonly, infections of the ears or eyes may cause cavernous sinus thrombosis Septic Cavernous Venous Thrombosis can result in the central nervous system or infectious pulmonary complications. Because the dural venous & cavernous system is valveless, this venous blood can communicate with the dural sinuses & cerebral & emissary veins leading to meningitis, dural empyema or brain abscess Septic cavernous sinus thrombosis • Most commonly results from contiguous spread of infection from the nose (50%), sphenoidal or ethmoidal sinuses (30%) and dental infections (10%). • Staphylococcus aureus is the most common - found in 70% of the cases. • Streptococcus is the second leading cause
MRI features are suggestive of purulent sinsusitis complicated by orbital infection (pre-and postseptal cellulitis) with optic neuritis and cavernous sinus thrombosis. Additional contributor: Assoc Prof MF Rougui, head of ophthalmology depart.. Bilateral septic cavernous sinus thrombosis following the masticator and parapharyngeal space infection from the odontogenic origin: a case report. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2010. Siriporn Hirunpat. Weerawat Kiddee. Passorn Preechawai These symptoms were suggestive of bilateral cavernous sinus syndrome. CT of the brain showed bilateral proximal internal jugular vein and cavernous sinus thrombosis. CT angiography revealed septic emboli at both upper lungs. The patient had good improvement of neurological symptoms after dental extraction, intravenous antibiotic and anticoagulant
Septic Cavernous Sinus Thrombosis: A Case Report By Lai PF, Raghunandan K, Ferri FF, Kiddee W, Southwick FS, Yarington CT, Bousser MG and Fishman RA Cit • Because of its complex neurovascular anatomic relationship, cavernous sinus thrombosis is the most important of any intracranial septic thrombosis. • Cavernous sinus thrombosis is usually a late complication of an infection of the central face or paranasal sinuses. Laupland KB. Vascular and parameningeal infections of the head and neck Septic cavernous sinus thrombosis is a rare but serious complication of infection of the cavernous sinuses. There are no randomised, controlled trials of management of this condition and existing reviews of the literature are somewhat dated. The authors report a case with a favourable outcome and then present the findings of a literature review.
Septic cavernous sinus thrombosis Septic cavernous sinus thrombosis Andrews, Charles M; Hawk, Harris E; Holmstedt, Christine A 2014-01-01 00:00:00 Introduction Sinus venous thrombosis represents a common, but often misdiagnosed, form of cerebrovascular disease. Infectious sinus venous thrombosis, although rare, has a much different clinical course and treatment than non‐infectious thrombosis In a patient with septic thrombosis of the cavernous sinuses CT demonstrated multiple filling defects due to clot formation, but 1.5 T MRI showed an atypical appearance of the thrombus, possibly because of the sepsis Septic cavernous sinus thrombosis Most commonly results from contiguous spread of infection from the nose (50%), sphenoidal or ethmoidal sinuses (30%) and dental infections (10%). Staphylococcus aureus is the most common - found in 70% of the cases. Streptococcus is the second leading cause. Gram-negative rods and anaerobes may also lead to. Southwick (2016) Septic Dural Sinus Thrombosis, UpToDate, accessed online 4/8/2016 (2016) Sanford Guide, accessed on IPad App 4/8/201 Cavernous Sinus Thrombosis is a serious, rare, life-threatening condition in which blood clots are formed in one of the structures in the skull, called the cavernous sinus. The cavernous sinus is a hollow space situated at the bottom of the brain, behind each eye socket). The cavernous sinuses drain venous (deoxygenated) blood from the facial.
Septic thrombophlebitis of cavernous sinus Concepts: Disease or Syndrome (T047) SnomedCT: 302879007: English: Sept thrombophlebit cavern sin, Septic thrombophlebitis of cavernous sinus (diagnosis), thrombophlebitis septic of cavernous sinus, Septic thrombophlebitis of cavernous sinus, Septic thrombophlebitis of cavernous sinus (disorder Infratentorial empyema, pituitary abscess, and septic cavernous sinus thrombophlebitis (CST) are all rare conditions. In the largest series to date, infratentorial empyema accounted for only 0.6% of all cases of intracranial suppuration ().In a recent review of the literature, Jain et al. identified only approximately 100 cases of pituitary abscesses